Bioscience · In-vitro safety
Screen for safety early, without animals.
CSL scientists screen raw materials and formulas for cell toxicity, irritation and skin-sensitisation potential at the Guires R&D Innovation Centre, so problems are found before money is spent on full safety studies.
Guires Cosmetic Science Lab
Animal-free Cosmetic Safety Screening from Guires CSL
At Guires Cosmetic Science Lab, CSL scientists run animal-free cosmetic safety screening at the Guires R&D Innovation Centre: cell toxicity, irritation and skin-sensitisation screening of raw materials and formulas, with regulatory-grade GLP studies arranged where needed.
Start your project with Guires CSLWhat's included
The work, in detail.
Cell toxicity
MTT and neutral red uptake assays that show the concentration at which an ingredient harms skin cells.
Skin sensitisation screening
Screening based on the h-CLAT principle (OECD 442E), which measures activation markers on immune-type cells by flow cytometry. Set up per project.
Irritation screening
Irritation screening on reconstructed human epidermis tissue kits, following the principle of OECD 439. Set up per project.
Ingredient comparison
Side-by-side screening of alternative suppliers or grades, so the gentlest option is chosen early.
Route to regulatory data
Where a safety file needs validated or GLP data, CSL arranges the full validated or GLP study.
Deliverables
What you receive.
How it runs
Step by step.
- BriefMaterials, intended use and markets
- PlanAssays and concentrations
- ScreenToxicity, irritation and sensitisation screens
- ReportResults and recommendations
- Full studyRegulatory-grade study if needed
Results from the Guires R&D Innovation Centre support formulation decisions, ingredient selection and claims development. Where a market or retailer needs regulatory-grade data, such as GLP safety studies or accredited test reports, CSL arranges those studies as part of the project.
Questions
Asked before we start.
Is this a replacement for the safety assessment?
No. Screening helps you choose safe ingredients and levels early. The cosmetic safety assessment is still written by a qualified safety assessor, using all available data.
Are these results accepted by regulators?
They are screening data. For regulatory submissions, CSL arranges validated or GLP studies.
Do you use animal testing?
No. All screening uses cell and tissue models.
More from the lab
Related bioscience services.
Start a project
Create your next product with CSL.
Our formulation chemists, testing scientists and regulatory specialists work alongside your team, from the first brief to a market-ready product. Bring a brief, a benchmark or just an idea: a scientist will reply within one working day with next steps and an indicative scope.