Bioscience · Biotech actives
Biotech actives, from strain to powder.
CSL scientists develop and scale fermented ingredients, postbiotic lysates and other biotech actives at the Guires R&D Innovation Centre, from 5 L trials to 100 L pilot batches and freeze-dried powders.
Guires Cosmetic Science Lab
Fermented Cosmetic Ingredients from Guires CSL
At Guires Cosmetic Science Lab, CSL scientists develop fermented cosmetic ingredients and postbiotic actives at the Guires R&D Innovation Centre, from strain selection and 5 L trials to 100 L pilot fermentation, purification and freeze-dried powders, with every batch checked for identity and activity.
Start your project with Guires CSLWhat's included
The work, in detail.
Strain and process development
Selection of the producing strain, growth medium and fermentation conditions for the active you want, with yield and quality tracked batch by batch.
Ferments and postbiotic lysates
Ferment filtrates, heat-treated lysates and postbiotic ingredients for skin, scalp and microbiome-friendly products.
Scale-up from 5 L to 100 L
Process transferred from 5 L to 40 L and 100 L fermentors, with the parameters that keep the active consistent at larger volume.
Harvest and purification
Cell separation, concentration and clean-up by centrifugation, homogenisation, tangential flow filtration and chromatography.
Freeze-dried and stable formats
Lyophilised powders and concentrated liquids that store well and dose easily into finished products.
Strain banking
Master and working cell banks of your strain, stored at −80 °C and in liquid nitrogen.
Activity and identity checks
Each batch checked for identity, purity and activity, from UPLC and gel analysis to cell-based efficacy assays.
Deliverables
What you receive.
How it runs
Step by step.
- BriefTarget active, claim and volume
- FeasibilityLiterature and small-scale trials
- OptimiseMedium, conditions and yield at 5 L
- Scale40 L and 100 L pilot runs
- DownstreamHarvest, purify, concentrate, dry
- Hand-overMaterial, specification and process pack
Results from the Guires R&D Innovation Centre support formulation decisions, ingredient selection and claims development. Where a market or retailer needs regulatory-grade data, such as GLP safety studies or accredited test reports, CSL arranges those studies as part of the project.
Questions
Asked before we start.
Can you work with our own strain?
Yes. CSL scientists can bank and ferment a strain you supply, under a confidentiality agreement, and the process stays yours.
What volumes can you make?
From laboratory flasks up to 100 L fermentor batches, enough for formulation, stability and consumer testing. Commercial volumes are transferred to a contract manufacturer.
Are biotech ingredients accepted in cosmetics?
Yes, in most markets, provided the ingredient has a safety assessment, a suitable INCI name and documentation. CSL regulatory specialists prepare this with you.
More from the lab
Related bioscience services.
Start a project
Create your next product with CSL.
Our formulation chemists, testing scientists and regulatory specialists work alongside your team, from the first brief to a market-ready product. Bring a brief, a benchmark or just an idea: a scientist will reply within one working day with next steps and an indicative scope.