Glossary · Actives

Retinoids

What it means

Vitamin A derivatives used in cosmetics, including retinol, retinal and retinyl esters. In the EU, Regulation (EU) 2024/996 caps retinol and its esters at 0.05% retinol equivalent in body lotions and 0.3% in other leave-on and rinse-off products.

Sources: 12

Why it matters

The right active at the right level and pH is what makes a claim credible; Guires CSL scientists choose actives on published evidence and check every level against the rules of your target markets.

How Guires CSL applies it

Guires CSL formulation, testing, clinical and regulatory teams work with Retinoids on client projects every week, from the first brief to the final product file.

Retinol evidence

References

  1. Regulation Commission Regulation (EU) 2024/996 of 3 April 2024 amending Regulation (EC) No 1223/2009 as regards the use of Vitamin A, Alpha-Arbutin and Arbutin and certain substances with potential endocrine disrupting properties in cosmetic products. eur-lex.europa.eu
  2. Peer-reviewed Mukherjee S, Date A, Patravale V, Korting HC, Roeder A, Weindl G. Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clin Interv Aging. 2006;1(4):327-348. pubmed.ncbi.nlm.nih.gov

Regulations and standards are listed first, then peer-reviewed literature. Sources checked October 2026.

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